AlpHelix and Membrane Proteins

What are membrane proteins

Membrane proteins (MPs) are proteins that are embedded in the cell membrane or the membrane of an intracellular organelle...

What are membrane proteins

Membrane proteins (MPs) are proteins that are embedded in the cell membrane or the membrane of an intracellular organelle...

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Membrane proteins are major drug targets in disease treatment

More than 90% of the targets of therapeutic antibody drugs or immunotherapies are membrane proteins (MPs)...

Membrane proteins are major drug targets in disease treatment

More than 90% of the targets of therapeutic antibody drugs or immunotherapies are membrane proteins (MPs)...

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AlpHelix specializes in the structural biology of membrane proteins

The transmembrane proteins,typically hydrophobic in their membrane-embedded...

AlpHelix specializes in the structural biology of membrane proteins

The transmembrane proteins, typically hydrophobic in their membrane-embedded regions...

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Technology Platform

  • Structural Biology

    Historically, drug research related to membrane protein targets has been hampered by difficult protein expression and three-dimensional structure studies. Learn More >>
  • Cell Engineering

    Reporter cell lines play an important role in drug discovery owing to their high-throughput, reliable output, and cost-effectiveness. Learn More >>
  • New Chemical Entity and Antibody Discovery

    The MP targets, by engineering a small number of single point mutations outside of the ligand-binding pocket Learn More >>
  • Bispecific Antibodies

    Alphelix applies a versatile approach to directly generate common light chain bispecific antibodies by using yeast surface display of heterodimeric IgG-like bispecific antibody Learn More >>
  • Functional Validation

    Validation of drug candidates at the molecular cellular and animal levels Learn More >>

Membrane Protein Services

AlpHelix provides services including large-scale overexpression, purification and analysis of difficult-to-express MPs, as well as three-dimensional structure determination, structure-based drug screening, and directed evolution of proteins. MPs covered by these services include: GPCRs, ion channels, transporters, transmembrane proteases (TPs), membrane receptors (other than GPCRs), and kinases.

Company Profile

AlpHelix Biosciences is a high-tech biotech company that contributes to the discovery of innovative biopharmaceuticals. We focus on membrane proteins (including ion channels, transporters, and GPCRs) and challenging Kinases. The main services of AlpHelix include overexpression and purification of membrane proteins, biophysical and biochemical characterization of these proteins, high-throughput ligand/drug screening using report cells, monoclonal/bispecific antibody discovery and engineering based on yeast surface display of full-length IgG, structure determination using X-ray crystallography and cryo-electron microscopy, and drug discovery and optimization based on the protein structures.

AlpHelix has built advanced technology platforms such as "structural biology," "cell engineering," "antibody and new chemical entity discovery," and "functional verification," and has established cooperative relationships with many well-known pharmaceutical companies and biotechnology companies to conduct research and development collaborations on small molecule, antibody, and peptide drugs targeting GPCRs, ion channels, and transporters.

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For more information about our technology and services, please contact us.

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